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KMID : 1157520110070010015
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International Journal of Clinical Preventive Dentistry
2011 Volume.7 No. 1 p.15 ~ p.18
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Estrogen Receptor β Gene Polymorphisms and Osteoporosis Risk in Postmenopausal Women in Need of Dentures
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Kusdhany Lindawati S.
Auerkari Elza I.
Suryandari Dwi A.
Rahardjo Tribudi W.
Hogervoorst Eef
Talbot Christopher
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Abstract
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Objective: Osteoporosis is a disease of bone metabolism, characterized by reduced density of e.g. the jawbone, with decreasing stability of the denture. Polymorphism in the estrogen receptor β gene (ER-β) has been linked with susceptibility to osteoporosis in ageing persons. The present study aimed to evaluate the association between the ER-β gene polymorphism and osteoporosis in Indonesian postmenopausal women.
Methods: The research was a cross-sectional study of 288 subjects that were 47-75 years old. Bone density was determined by an ultrasonic technique and the subjects were divided on this basis into normal, osteopenia and osteoporosis groups. Peripheral blood samples were used for DNA isolation, and the ER-β polymorphism status of the subjects was evaluated using the PCR-RFLP technique with Alu1 restriction enzyme for cutting. Chi-square testing was used to evaluate the relation between the polymorphism status and the observed bone density.
Results: The results showed that the status of ER-β polymorphism is significantly associated with osteoporosis in Indonesian postmenopausal women. In particular, a high fraction (68%) of subjects with osteoporosis were of the AA genotype, while osteoporosis was less common (32%) in the Aa genotype and apparently rare in the aa genotype that was in case uncommon.
Conclusion: The majority of subjects with osteoporosis were of the AA genotype in terms of ER-β polymorphisms in Indonesian postmenopausal women. As the majority of all subjects were of AA genotype, the results support the view that expression of ER-β would increase the risk to osteoporosis and fracture in ageing women.
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KEYWORD
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estrogen receptor β, gene polymorphism, osteoporosis, postmenopausal woman, denture
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